The opinion of experts is that the disease is present from birth. However, symptoms can begin in adolescence or even later in life. While some patients begin to experience symptoms from childhood, some patients may show their first symptoms in their 50s.

Redness of the skin due to the disease can cause itching and pain. However, in the vast majority of patients, the symptoms remain at a level that only affects the physical appearance. The disease can be triggered by the general health of the person, the stress he is exposed to in his daily life and the diet.